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Summary of clinical features

Authoring team

Diffuse cutaneous systemic sclerosis is characterised by:

  • Raynaud's phenomenon
  • onset of skin involvement within 1 year of Raynaud's
  • truncal and acral skin involvement
  • tendon friction rubs
  • interstitial lung disease
  • renal failure
  • nailfold telangiectasia

Immunological investigation may reveal:

  • anti-topoisomerase-I antibody

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