is a single chain basic protein with low molecular weight (13 kD) produced by all nucleated human cells, whose circulating concentrations can be easily determined by an automated particle-enhanced immunoturbidimetric method
mainly filtrated by the kidney
other factors affecting the production of Cystatin C include the use of systemic glucocorticoids and thyroid dysfunction
Cystatin C and microalbuminuria are considered early markers of kidney damage
Cystatin C could be affected by changes in body composition. Indeed, fat-free mass, a parameter inversely related to age, affects CysC level, and in older patients with chronic kidney disease CysC-based GFR estimation improves when fat-free mass is taken into account (1)
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