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Renal features of Wegener's granulomatosis

Authoring team

The renal manifestations of Wegener's granulomatosis include:

  • glomerulonephritis
  • haematuria
  • proteinuria
  • azotaemia

Renal involvement occurs in about 77% of cases - in contrast to polyarteritis nodosa, hypertension is an unusual feature of Wegener's granulomatosis.

Notes:

  • patients may present with life-threatening renal failure due to rapidly progressive glomerulonephritis requiring urgent dialysis and immunosuppression
  • at the other end of the spectrum are patients with proteinuria or haematuria with no impairment of renal function
  • any renal involvement is associated with a significantly worse outcome

Reference:

  • 1) ARC Autumn 2012. Topical Reviews - ANCA-associated vasculitis; 1:1-12.

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