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Switching antidepressant (vortioxetine to moclobemide) in adults

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Vortioxetine to moclobemide

Taper, washout and switch

  • gradually reduce the dose of vortioxetine and stop; wait 7 days before starting low dose moclobemide

  • cross-tapering is not recommended due to the high risk of serotonin syndrome

  • is limited experience with this switch so extra caution is required to avoid serotonin syndrome (1)

Reference:

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