This site is intended for healthcare professionals

Sign in
Go to /sign-in page

You can view 5 more pages before signing in

Switching antidepressant - SNRI (e.g. duloxetine or venlafaxine) to tricyclic antidepressants (TCAs) in adults

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

SNRIs to tricyclic antidepressants (TCAs)

Switching to dosulepin requires specialist advice and should not be done in primary care due to the increased cardiac risk and toxicity in overdose (1).

To all except clomipramine

Cross-taper

  • cross-tapering, starting with a low dose tricyclic antidepressant can usually be undertaken cautiously over 2 to 4 weeks, the speed is determined by individual tolerability.

To clomipramine

Taper, stop and switch

  • gradually reduce the dose of the SNRI and stop. Start low dose clomipramine the following day
  • cross-tapering is not recommended and should only be undertaken if specialist advice is in place, this is because clomipramine is a potent serotonin reuptake inhibitor so there is a high risk of serotonin syndrome

Reference:

Related pages

Create an account to add page annotations

Create a free account

Annotations allow you to add information to this page that would be handy to have on hand during a consultation. E.g. a website or number. This information will always show when you visit this page.

The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.

Connect

Copyright 2024 Oxbridge Solutions Limited, a subsidiary of OmniaMed Communications Limited. All rights reserved. Any distribution or duplication of the information contained herein is strictly prohibited. Oxbridge Solutions receives funding from advertising but maintains editorial independence.