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Choroquine and psychiatric complications

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

Hydroxychloroquine and chloroquine are ssociated with psychiatric reactions, including reports of depression, anxiety, hallucinations, and psychosis (1)

Advice to patients (1):

  • advise patients taking hydroxychloroquine or chloroquine medicines to contact a doctor immediately if they experience new or worsening mental health problems (such as irrational thoughts, anxiety, hallucinations, and feeling confused or feeling depressed, including thoughts of self-harm or suicide)

  • family members or caregivers may also be advised to be vigilant for these reactions and the need to seek medical advice if they occur

Reference:

  • MRHA. Hydroxychloroquine, chloroquine: increased risk of cardiovascular events when used with macrolide antibiotics; reminder of psychiatric reactions. Drug Safety Update volume 15, issue 7: February 2022: 2
  • Mubagwa K. Cardiac effects and toxicity of chloroquine: a short update. Int J Antimicrob Agents. 2020;56(2):106057. doi:10.1016/j.ijantimicag.2020.106057

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