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Child developmental risk factors for adult schizophrenia

Authoring team

The following risk factors for schizophrenia were demonstrated in a prospective cohort study of 5362 individuals born in one week in 1946:

  • motor milestones were delayed in children who later developed schizophrenia (difference 1.2 months, p=0.005)

  • up to age 15 cases had more speech problems (odds ratio 2.8 p=0.04)

  • low educational test scores were a risk factor

  • solitary play preference at ages 4 and 6 predicted schizophrenia (OR 2.1 and 2.5 p=0.05)

  • teachers assessed cases as being more anxious in social situations (p=0.003)

  • health visitors assessed mothers of cases at age 4 years as having poor mothering skills (OR 5.8 p=0.02)

Reference:

  • Jones, P. et al. (1994). Child developmental risk factors for adult schizophrenia in the British 1946 cohort. Lancet 344, 1398-1402.

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