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Modification of the response to radiation

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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In tissues exposed to radiation curves can be drawn of damage versus dose. Tumours and normal tissues have different curves such that a dose which causes 90% tumour damage only damages 60% of normal tissue. The aim of radiobiology is to separate the curves.

The following strategies are employed to modify the damage:

  • radiosensitisers
  • radioprotectors
  • dose rate - higher the better the killing
  • dose fractionation
  • treatment of irradiated fields

Thus:

  • repair of sublethal damage
  • reassortment of cells within the cell cycle
  • repopulation - if overall time is sufficiently long
  • reoxygenation

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