Prothrombin G20210A is due to a single base change in the 3' untranslated region of the prothrombin gene and is associated with an elevated plasma level of prothrombin.
There is increasing evidence that individuals with two or more laboratory characterisable thrombophilic abnormalities (or who are homozygous for either factor V Leiden or prothrombin G20210A) are at a greater risk of thrombosis than those in whom there is a single gene abnormality (1)
Reference:
(1) British Heart Foundation (Factfile 2/2002). Thrombophilia
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