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PGE1

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

Prostaglandin E1 has the following functions:

  • along with PGE2, maintains ductus arteriosus patency in the newborn as a result of its general vasodilatory effect
  • inhibits platelet aggregation
  • gastric effects:
    • increases cellular resistance to acid
    • increased mucous secretion
    • decreased acid secretion
  • increases uterine contraction
  • gastrointestinal tract: increases contraction and secretion
  • negative inotropy on heart
  • hypothalamic pyretic

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