Mutations in the gene for the mannose binding protein (MBP) may result in defective opsonisation. This common form of immuno-deficiency causes recurrent infections in children and severe and unusual infections in adults.
MBP mutations are found in 25% of children with unexplained recurrent bacterial and fungal infections (1).
The normal form of MBP may have a role in the pathogenesis of rheumatoid arthritis.
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