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Aspirin and secondary stroke prophylaxis in NRAF

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

Stroke or TIA in patients with non rheumatic atrial fibrilation in whom intracranial haemorrhage has been excluded should be given aspirin:

  • in NRAF aspirin prevents 40 vascular events per 1000 patient years of treatment (1).
  • definitive anti-platelet therapy should be commenced at 2 weeks post symptoms

Anticoagulation should be introduced subsequently:

  • in NRAF anticoagulation prevents 90 vascular events per 1000 patient years of treatment (1).


  • (1) European Atrial Fibrillation Trial Study Group. Secondary prevention in non-rheumatic atrial fibrillation after transient ischaemic attack or minor stroke. Lancet, 1993;342: 1255.

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