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Nitrogen mustards

Authoring team

Nitrogen mustards are bifunctional alkylating agents - ie they are able to cross link two DNA strands. Cyclophosphamide - metabolised to alkylating species nd acrolein - iv and po - widely used, especially in breast cancer Melphalan - phenylalanine mustard - marrow ablative therapy - multiple myeloma, po Chlorabucil - CLL and Hodgkins disease

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