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Types

Last reviewed Mar 2, 2022

Two broad types of ductal carcinoma in situ are recognised:

comedo-type tumours are characterised by:
- pleomorphic cells ductal epithelial cells obliterate the lumina of the ducts and grow along them
- eventually solid cords of anaplastic cells
- central necrosis
- microcalcification
- associated with multicentric disease
- high expression of C-erb2 oncogene
non-comedo type tumours are characterised by:
- variable histology:
  - cribriform
  - micropapillary
  - clinging
  - solid
- less frequent:
- mitoses
  - necrosis
  - calcification

Often, comedo and non-comedo types occur simultaneously.

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