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There are three broad groups of chemotherapeutic drugs, depending on the toxicity and the phase of the cell cycle:

  • toxicity independent of phases of cell cycle, including Go
  • specific to the cell cycle, but not active in Go
  • phase specific drugs, e.g. only in S phase

Principles:

  • a constant fraction of tumour cells are killed by a given dose of a given drug
  • there is a dose-response relationship

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