Advice regarding use of aspirin in pregnancy to reduce risk of preeclampsia has been outlined by NICE (1)
Advise pregnant women at high risk of pre-eclampsia to take 75-150 mg of aspirin [*] daily from 12 weeks until the birth of the baby.
Women at high risk are those with any of the following:
Advise pregnant women with more than 1 moderate risk factor for preeclampsia to take 75-150 mg of aspirin[*] daily from 12 weeks until the birth of the baby. Factors indicating moderate risk are:
[*] Although this use is common in UK clinical practice, at the time of publication (June 2019), aspirin did not have a UK marketing authorisation for this indication. Community pharmacies cannot legally sell aspirin as a pharmacy medicine for prevention of pre-eclampsia in pregnancy in England. Aspirin for this indication must be prescribed. The prescriber should see the summary of product characteristics for the manufacturer's advice on use in pregnancy. The prescriber should follow relevant professional guidance, taking full responsibility for the decision. Informed consent should be obtained and documented. See the General Medical Council's Prescribing guidance: prescribing unlicensed medicines for further information.
A systematic review (2) concluded that:
Reference:
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