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Managing relapse after radical treatment

Authoring team

NICE suggest that (1):

  • analyse serial PSA levels after radical treatment using the same assay technique

  • biopsy of the prostatic bed should not be performed in men with prostate cancer who have had a radical prostatectomy

  • biopsy of the prostate after radiotherapy should only be performed in men with prostate cancer who are being considered for local salvage therapy in the context of a clinical trial

  • for men with evidence of biochemical relapse following radical treatment and who are considering radical salvage therapy:
    • routine MRI scanning should not be performed prior to salvage radiotherapy in men with prostate cancer
    • an isotope bone scan should be performed if symptoms or PSA trends are suggestive of metastases

  • biochemical relapse (a rising PSA) alone should not necessarily prompt an immediate change in treatment

  • biochemical relapse should trigger an estimate of PSA doubling time, based on a minimum of 3 measurements over at least a 6 month period

  • men with biochemical relapse after radical prostatectomy, with no known metastases, should be offered radical radiotherapy to the prostatic bed

  • men with biochemical relapse should be considered for entry to appropriate clinical trials

  • hormonal therapy is not routinely recommended for men with prostate cancer who have a biochemical relapse unless they have:
    • symptomatic local disease progression, or
    • any proven metastases, or
    • a PSA doubling time of < 3 months

Reference:


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