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Regulation

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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The regulation of glycogen synthase is best considered in terms of:

  • hepatic enzyme regulation
  • skeletal muscle regulation

The key differences between the sites are:

  • hepatic glycogen synthase is more closely related to the intracellular glucose concentration, which is in equilibrium with the plasma glucose concentration, than skeletal muscle glycogen synthase
  • hepatic glycogen synthase is modulated more closely by both glycogen and insulin
  • skeletal glycogen synthase is more sensitive to changes in intracellular calcium concentration

Glycogen synthase acts in opposition to glycogen phosphorylase; the interaction between the two physiological antagonists is considered in the submenu.

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