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Epidemiology of duodenal ulcer

Authoring team

  • four times more common in men than women
  • most common in middle age - peak 30-50 years
  • strong genetic influence:
    • three times more common in first degree relatives of patients with an ulcer than in the general population
    • more common in patients with blood group O
    • more common in non-secretors of ABO blood group antigens into body fluids such as saliva
    • increased incidence in white males with HLA-B5 antigen
    • associated with increased serum pepsinogen
  • reportedly lower incidence in lower socio-economic groups
  • Helicobacter pylori infection is often seen - over 95% of patients with a duodenal ulcer are infected with H. pylori
  • smoking is twice as common in patients with chronic peptic ulceration than the general population

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