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Cytochrome c oxidase

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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Cytochrome C oxidase is an enzyme of the inner mitochondrial membrane that is part of the electron transfer chain. It is made up of at least 8 subunits and has two coenzymes:

  • cytochrome a
  • cytochrome a3

Cytochrome C oxidase accepts electrons from cytochrome c and transfers them to oxygen. Ultimately, oxygen is converted to water and a proton is pumped across the inner membrane to the mitochondrial intermembranous space. This proton is used to create ATP during oxidative phosphorylation.


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