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Unusual manifestations

Authoring team

Unusual manifestations of Whipple's disease include:

  • central nervous system:
    • dementia
    • ophthalmoplegia
    • myoclonus
    • oculomasticatory movements:
      • convergent eye movements with simultaneous chewing movements

  • cardiac:
    • fibrous pericarditis
    • myocarditis
    • lesions of the mitral and aortic valves

  • pulmonary:
    • pleural effusion
    • chronic cough
    • mediastinal widening caused by adenopathy

  • a sarcoidosis-like syndrome:
    • the PCR test for T. whippelii should be used in patients with a diagnosis of sarcoidosis

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