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Regulation (citrate synthase)

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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Citrate synthase catalyzes a non-equilibrium, flux-generating reaction.

It is stimulated by oxaloacetate. This is important during exercise because the enzyme pyruvate carboxylase produces significantly more oxaloacetate.

It is inhibited by citrate. Exercise produces a greater proportionate activation of the enzymes isocitrate dehydrogenase and oxoglutarate dehydrogenase. Hence, there is a relative reduction in the amount of citrate and a relative disinhibition of citrate synthase.


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