This site is intended for healthcare professionals

Sign in
Go to /sign-in page

You can view 5 more pages before signing in

Drug modulation

Authoring team

Clinical therapeutics target the arachidonic acid pathway in several ways:

  • inhibition, primarily producing anti-inflammatory effects:
    • glucocorticoid steroids promote the production of lipocortin, a substance which inhibits arachidonic acid metabolism
    • non-steroidal anti-inflammatory drugs inhibit cyclo-oxygenase
  • stimulation:
    • PGE2 and PGF2 alpha are used as abortifacients
    • PGE1 is used to keep the ductus arteriosus patent prior to surgery for congenital heart defects
    • PGI2 is used to decrease pulmonary hypertension in neonates

Related pages

Create an account to add page annotations

Create a free account

Annotations allow you to add information to this page that would be handy to have on hand during a consultation. E.g. a website or number. This information will always show when you visit this page.

The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.

Connect

Copyright 2025 Oxbridge Solutions Limited, a subsidiary of OmniaMed Communications Limited. All rights reserved. Any distribution or duplication of the information contained herein is strictly prohibited. Oxbridge Solutions receives funding from advertising but maintains editorial independence.