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Semen Strychni (SS)

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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Semen Strychni (SS)

  • the dried seeds of Strychnos nux-vomica L. (Loganiaceae), is bitter and warm and, according to the TCM (Traditional Chinese Medicine) theory, belongs to the liver and spleen meridians (1,2)
    • dry mature seeds are disc-shaped, slightly concave, and hard
    • SS was first recorded in the Compendium of Materia Medica in Ming Dynasty and is now collected by the Chinese pharmacopeia

  • SS can be used to treat rheumatoid arthritis, facial nerve paralysis, amyotrophic lateral sclerosis and Myasthenia Gravis (MG) (1,2)
    • the main toxic component of SS is strychnine
    • alkaloids have been found to be the main active ingredient in SS, which includes strychnine, brucine and other nitrogen oxides

Reference:

  1. Fang P et al. Study on the Potential Mechanism of Semen Strychni against Myasthenia Gravis Based on Network Pharmacology and Molecular Docking with Experimental Verification. Evid Based Complement Alternat Med. 2022 Oct 1;2022:3056802.
  2. Tang X et al. Exploring the mechanism of Semen Strychni in treating amyotrophic lateral sclerosis based on network pharmacology. Medicine (Baltimore). 2023 Sep 8;102(36):e35101.

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