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Iatrogenic Creutzfeldt-Jacob disease

Authoring team

The use of prion-contaminated medication, grafts and instruements may result in iatrogenic Creutzfeldt-Jacob disease (CJD).

The clinical features of the disease vary according to the route of innoculation.

Central innoculation, such as an infected dural graft, results in a rapidly progressive neurodegenerative disease similar to sporadic CJD, characterised by:

  • ataxia
  • dementia
  • myoclonus
  • rididity
  • akinetic mutism
  • survival is 2-12 months from presentation

Peripheral innoculation, such as the old human growth hormone products, results in a slightly less acute disease disease characterised by:

  • progressive cerebellar ataxia
  • dementia is not invariably present
  • survival is 8-18 months from presentation

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The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.

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