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Comparison of Alzheimer's disease and DLB

Last edited May 24, 2022. Last reviewed Jun 20, 2022

Authoring team

The following features may help to differentiate Alzheimer's disease (AD) from dementia with Lewy bodies (DLB):

memory loss:
- AD: usually the presenting feature with significantly worse memory functioning
- DLB: memory may be relatively normal in the early stages
course:
- AD: progressive
- DLB: progressive with marked fluctuations
parkinsonism (unsteady gait, bradykinesia, cogwheeling):
- AD: late stages
- DLB: early stages
hallucinations:
- AD: not a major feature
- DLB: a hallmark feature.

Reference:

(1) Crowell TA, Luis CA, Cox DE, Mullan M. Neuropsychological comparison of Alzheimer's disease and dementia with lewy bodies. Dement Geriatr Cogn Disord. 2007;23(2):120-5. doi: 10.1159/000097791.

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