This site is intended for healthcare professionals

Go to /sign-in page

You can view 5 more pages before signing in

Carbamazepine and Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) in Thai and Han Chinese people (HLA-B*1502)

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

NICE gudiance notes that the Guideline Development Group are aware of the contraindications to prescribing carbamazepine (CBZ)to some people of Han Chinese or Thai origin (1)

CBZ has been reported to be associated with severe cutaneous adverse drug reactions including Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN)

  • postmarketing data provided by the leading CBZ manufacturer, revealed the incidence of CBZ-induced SJS/TEN in several Asian countries was 10-fold higher than those reported in European countries and the United States

  • data from the World Health Organization Uppsala Monitoring Center (WHO-UMC) reveals reports of CBZ-associated SJS and TEN from the two Asian countries, Thailand and Malaysia, are far in excess of those from the predominantly European countries

  • study evidence in Han Chinese showed that the HLA-B* 1502 allele is strongly associated with CBZ-induced SJS and TEN (2,3,4)
    • in contrast to the association reported in Han Chinese, the association between HLA-B*1502 and CBZinduced SJS/TEN could not be demonstrated in Caucasians (5)

  • study evidence also shows that HLA-B*1502 is strongly associated with CBZ-induced TEN/SJS in the Malay population in Malaysia, as has been seen in Han Chinese in Taiwan (4)
    • the study authors concluded that " this indicates that the genetic association apparent in the incidence of CBZ-induced TEN/SJS is linked with the presence of HLA-B*1502, irrespective of racial origin. Screening of patients for this genetic marker can help to prevent the occurrence of TEN/SJS..."

Reference:


Related pages

Create an account to add page annotations

Annotations allow you to add information to this page that would be handy to have on hand during a consultation. E.g. a website or number. This information will always show when you visit this page.

The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.

Connect

Copyright 2024 Oxbridge Solutions Limited, a subsidiary of OmniaMed Communications Limited. All rights reserved. Any distribution or duplication of the information contained herein is strictly prohibited. Oxbridge Solutions receives funding from advertising but maintains editorial independence.