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Amantadine in parkinsonism

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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Amantadine increases dopamine release and inhibits its uptake at dopaminergic synapses.

It may be effective in mild parkinsonism. The usual dose in 100mg bd. An effect is usually evident within 3 days.

Amantadine may be used as a treatment for people with early Parkinson's disease (PD) but should not be a drug of first choice (1).

Amantadine may be used to reduce dyskinesia in people with later PD (1).

Reference:

  1. NICE (June 2006). Parkinson's disease

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