Paracetamol to prevent and treat fever after MenB vaccination
Fever can be expected after any vaccination, but is more common when the MenB vaccine (Bexsero) is given with the other routine vaccines at 8 and 12 weeks
without paracetamol, more than half of infants will develop a temperature after these vaccines
fever tends to peak around 6 hours after vaccination and is nearly always gone completely within 2 day
total of 3 doses of 2.5ml (60mg) of paracetamol are recommended following MenB vaccination
first should be given dose at the time of vaccination or as soon as possible afterwards
the second dose of paracetamol should be given around 4 to 6 hours later and a third dose 4 to 6 hours after that
for very premature babies (born before 32 weeks gestation), paracetamol should be prescribed according to the infant’s weight at the time of vaccination
giving paracetamol soon after vaccination – and not waiting for a fever to develop – will reduce the risk of your child having a fever.
with paracetamol, fewer than 1 in 5 children will get a fever and nearly all of these are mild (below 39°C)
paracetamol will also reduce the chance pain at the site of the injection
paracetamol is not routinely needed after the Men B booster vaccine given at 12 months of age
by this age the baby’s risk of fever is the same as after other vaccines
Notes:
paracetamol is approved for managing fever in children from the age of 2 months
as fever after vaccination is common, experts have advised that it is OK to give paracetamol for up to 48 hours after the MenB vaccine without seeking medical advice (1)
fever in this time period is much more likely to be caused by the vaccine than by an infection
Reference:
UK Health Security Agency (June 2025). Using paracetamol to prevent and treat fever after MenB vaccination
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