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Side effects

Authoring team

The side effects of silver sulphadiazine include:

  • formation of pseudo-eschar: can make difficult the appreciation of invasive infection and burn depth
  • neutropenia:
    • occurs after a couple of days of administration
    • usually transient even with continued application
    • requires regular WCC assay
  • kerinicterus; do not use in:
    • pregnant mothers
    • children less than two months old
  • blood disorders:
    • haemolytic anaemia in patients with glucose-6-phosphate deficiency
    • methaemoglobinuria
  • maculopapular rash
  • silver deposits in the skin after application; this can lead to cosmetic problems and as such, it should never be applied to the face
  • can inactivate enzyme-debriding agents

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