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Unwanted effects

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

  • pneumococcal conjugate vaccine (PCV)
    • swelling and redness at the injection site and low grade fever are among the most commonly reported adverse reactions (10–20%)
    • no increased local or systemic reactions have been reported with repeated doses during the primary series, although a higher rate of transient tenderness has been reported after a fourth dose
  • pneumococcal polysaccharide vaccine (PPV)
    • mild soreness and induration at the site of injection lasting one to three days
    • lless commonly, a low grade fever may occur
    • more severe systemic reactions are infrequent. In general, local and systemic reactions are more common in people with higher concentrations of antibodies to pneumococcal polysaccharides

  • confirmed anaphylaxis involving pneumococcal vaccines is rare. Other allergic conditions, such as rashes, may occur more commonly and are not contraindications to further immunisation (1)


  1. Immunisation Against Infectious Disease - "The Green Book".Chapter 25 Pneumococcal (April 2019)
  2. Drug and Therapeutics Bulletin (1998); 36 (10): 73-6.

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