if 'spider bite' lesions are present, the possibility of CA-MRSA or Panton–Valentine leucocidin (PVL)-positive methicillin sensitive Staphylococcal aureus (MSSA) infection should be considered and appropriate investigation and management instituted
typical of cutaneous CA-MRSA infections
spontaneous appearance of a raised tender red lesion, which may progress to develop a necrotic centre
if there is a history of recurrent abscesses or household clusters of infection, the possibility of CA-MRSA or PVL-positive MSSA infection should be considered and appropriate investigation and management instituted
if there has been a prior poor response to ß-lactam therapy, the possibility of CA-MRSA or PVL-positive MSSA infection should be considered and appropriate investigation and management instituted
if there is a history of exposure to one or more antibiotics in the past year, especially quinolones or macrolides, the possibility of CA-MRSA infection should be considered and appropriate investigation and management instituted
risk factors for CA-MRSA include:
children <2 years old
athletes (mainly contact-sport participants)
injection drug users
men who have sex with men
military personnel
inmates of correctional facilities, residential homes or shelters
vets, pet owners and pig farmers
patients with post-flu-like illness and/or severe pneumonia
patients with concurrent skin and soft tissue injury
history of colonization or recent infection with CA-MRSA
history of antibiotic consumption in the previous year, particularly quinolones or macrolides
cultures should be taken from septic sites if:
CA-MRSA is suspected because of the risk assessment based on clinical presentation, treatment factors and other risk factors
there are recurrent furuncles or abscesses (two or more in 6 months)
there is a history of spread in the family or to others, e.g. sporting contacts (the information may be available from the public health/infection control team)
there is severe infection (extensive or progressive disease with evidence of systemic sepsis), the patient should be hospitalized and a skin/abscess culture and blood culture should be taken
do not take cultures routinely from patients presenting with minor SSTIs and without a history of previous MRSA
do not routinely aspirate material for culture from cellulitis in the absence of discharge or broken skin
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