All patients with AIDS-related, non-Hodgkin's lymphoma should have their disease fully staged with CT or MRI scans, bone marrow aspiration, CSF sampling and immunohistochemical staining.
Patients with high-grade lymphomas should then go on to receive combination chemotherapy followed by highly active anti-viral therapy (HAART).
Prophylaxis against Pneumocystis carinii pneumonia should also be considered.
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