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Empirical antibiotics

Authoring team

Prescription of antibiotics empirically is a balance between doing the job scientifically and doing it quickly. The hazards of prescribing empirically include:

  • resistant organism
  • superinfection
  • adverse effects
  • obscuring the diagnosis

Therefore, make a diagnosis, preferably a bacteriological one. Take specimens, if appropriate, and make a clinical diagnosis. The relevant section of the BNF and a local microbiology service will give the best bet of organism and the relevant antimicrobial therapy.

Therapy should be modified upon receipt of results of culture if appropriate.


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The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.

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