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Dane particle

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The complete hepatitis B virion is called the Dane particle. It is a DNA virus of the Hepadna family and consists of an outer envelope and core.

The core is formed in the hepatocyte nucleus. It contains:

  • partially double stranded circular DNA - there is a single stranded gap which is repaired by the DNA polymerase
  • DNA polymerase
  • core antigen - HBcAg
  • 'e' antigen - a protein sub-unit of the core - HbeAg

The outer envelope consists of protein, lipid and carbohydrate. It is made in the hepatocyte cytoplasm. The envelope contains the surface antigen, HbsAg.

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