COVID-19 is caused by the SARS-CoV-2 virus (a respiratory infectious disease)
Cognitive impariment after COVID-19
- most patients recover following COVID-19 with no sequelae - however there is growing evidence that COVID-19 may result in cognitive impairment (1)
- individuals with cognitive impairment following COVID-19 experience cognitive deficits, such as:
- diminished memory and attention
- sleep disturbances
- a review notes that (2)
- cognitive problems are common after acute SARS-CoV-2 infection
- study evidence suggests up to one third of patients with long COVID have cognitive impairment - however the review notes that estimates vary widely and are complicated by methodological heterogeneity—eg, study size, assessment approach, follow-up duration
- most frequent symptoms seem to affect memory, attention, and concentration
- discrete impairments are also seen in attentional and executive processing different types of memory, visuospatial processing, and language
- linked systemic symptoms such as fatigue, insomnia, and a general befuddled state frequently termed “brain fog” are commonly reported
- symptoms tend to improve, but this may take up to a year
- individuals with chronically persistent symptoms lasting more than 12 months have a lower chance of improving
- symptoms usually fluctuate
- evidence indicates that COVID-19 may contribute to cognitive decline by damaging crucial brain regions, including the hippocampus and anterior cingulate cortex (1)
- study evidence has identified active neuroinflammation, mitochondrial dysfunction, and microglial activation in COVID-19 patients, implying that these factors may be potential mechanisms leading to cognitive impairment (1)
Note that before considering cognitive impairment as secondary solely (or partly) due to COVID-19 that the clinician must (2):
- seek to exclude non-specific cognitive blunting from other underlying causes
- exclude specific metabolic, toxic, or (patho)physiological causes
- consider that poor sleep, diet, smoking, alcohol, and recreational drug use, reduced activity levels, and low exposure to natural light may also contribute
Reference:
- Li Z, Zhang Z, Zhang Z, Wang Z, Li H. Cognitive impairment after long COVID-19: current evidence and perspectives. Front Neurol. 2023 Jul 31;14:1239182
- Ladds E, Darbyshire J L, Bakerly N D, Falope Z, Tucker-Bell I. Cognitive dysfunction after covid-19 BMJ 2024; 384 :e075387 doi:10.1136/bmj-2023-075387