Epidemiology
As described in the classification section, there are three types of von Willebrand disease. Considering epidemiology from a UK perspective:
- Type 1 occurs in about 1% of the population; this is the most common type of von Willebrand disease accounting for about 75% of people with von Willebrand disease (1)
- Type 2 accounts for 20-30% of those with von Willebrand disease (2)
- Severe (type 3) VWD accounts for only 5% of cases and has an overall prevalence of 1 to 3 per million of the general population, but is relatively more common in countries or regions where consanguineous relationships are accepted. (3)
Reference
- Castaman G, Federici AB, Rodeghiero F, et al. Von Willebrand's disease in the year 2003: towards the complete identification of gene defects for correct diagnosis and treatment. Haematologica. 2003;88:94-108.
- Sadler JE, Budde U, Eikenboom JC, et al. Update on the pathophysiology and classification of von Willebrand disease: a report of the subcommittee on von Willebrand factor. J Thromb Haemost. 2006 Oct;4(10):2103-14.
- Srivastava A, Rodeghiero F. Epidemiology of von Willebrand disease in developing countries. Sem Thromb Hemost. 2005 Nov;31(5):569-76.
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