Features
- is rarely inherited in an X-linked manner
- primary sideroblastic anaemia:
- occurs in older adults
- characterised by progressive anaemia and hepatosplenomegaly
- neutropenia and thrombocytopenia may develop
- leucocyte alkaline phosphatase activity is generally low
- blood film:
- dimorphic picture with normal and hypochromic cells
- in congenital cases there may be microcytosis
- in acquired cases there may be macrocytosis
- blasts will be present in cases of acute myeloid leukaemia
- in lead poisoning there will be punctate basophilia in the red cells
- bone marrow:
- ring sideroblasts in the bone marrow
- erythroid hyperplasia
- iron studies:
- raised serum ferritin
- lowered TIBC
Reference
- Rodriguez-Sevilla JJ, Calvo X, Arenillas L. Causes and Pathophysiology of Acquired Sideroblastic Anemia. Genes (Basel). 2022 Aug 30;13(9)
Related pages
Create an account to add page annotations
Annotations allow you to add information to this page that would be handy to have on hand during a consultation. E.g. a website or number. This information will always show when you visit this page.