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Serum ACE in sarcoid

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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Sarcoidal granulomas produce angiotensin-converting enzyme (ACE)

  • elevated ACE levels are seen in 60% of sarcoidosis patients
  • levels are influenced by gene polymorphism (1)

Although many clinicians check serum ACE levels, the importance of it in the diagnosis or managing sarcoidosis is debatable (1,2):

  • as a diagnostic tool it has limited sensitivity and specificity (1)
  • BTS guidelines also mention that serum ACE levels has a limited role in the diagnosis and it does not contribute to monitoring patients with pulmonary sarcoidosis when added to serial lung function and imaging (3)


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