This site is intended for healthcare professionals

Go to /sign-in page

You can view 5 more pages before signing in

Nitrofurantoin induced agranulocytosis

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

Nitrofurantoin induced agranulocytosis

Idiosyncratic drug-induced agranulocytosis is a rare life-threatening adverse reaction characterised by an absolute neutrophil count <500 cells/muL of blood

A review noted (1):

  • with respect to cases of agranulocytosis associated with use of nitrofurantoin
    • agranulocytosis seemed to occur independently of renal function, but creatinine clearance <60 mL/min would be a risk factor
  • monitoring the total WBC, granulocyte count, and renal function may prevent agranulocytosis in patients treated with nitrofurantoin

A more recent review notes (2):

  • agranulocytosis is described as a possible adverse effect with unknown frequency in the summary of product characteristics of nitrofurantoin, but few cases worldwide have been reported

According to worldwide adverse drug reaction data, approximately 0.0004% of nitrofurantoin treatments have resulted in hematologic reactions (3).


Related pages

Create an account to add page annotations

Annotations allow you to add information to this page that would be handy to have on hand during a consultation. E.g. a website or number. This information will always show when you visit this page.