This site is intended for healthcare professionals

Sign in
Go to /sign-in page

You can view 5 more pages before signing in

Hageman (contact) factor

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

Factor XII, Hageman factor, is a plasma protein at the centre of a number of plasma protease cascades involved in inflammation. It is part of the beta-globulin fraction of plasma proteins.

It is activated by:

  • exposed collagen
  • basement membrane
  • endotoxin
  • negatively-charged surfaces
  • glass
  • endogenous substances e.g. kallikrein

It stimulates:

  • directly, the intrinsic pathway of blood coagulation
  • indirectly, the extrinsic pathway of blood coagulation
  • the kallikrein-kinin system
  • the plasmin fibrinolysis system
  • indirectly via kallikrein and plasmin, the complement cascade

Related pages

Create an account to add page annotations

Create a free account

Annotations allow you to add information to this page that would be handy to have on hand during a consultation. E.g. a website or number. This information will always show when you visit this page.

The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.

Connect

Copyright 2024 Oxbridge Solutions Limited, a subsidiary of OmniaMed Communications Limited. All rights reserved. Any distribution or duplication of the information contained herein is strictly prohibited. Oxbridge Solutions receives funding from advertising but maintains editorial independence.