This site is intended for healthcare professionals

Go to /sign-in page

You can view 5 more pages before signing in

Role of factor VIII in blood coagulation

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

Factor VIII acts as follows:

  • acceleration of the rate of cleavage of factor X by activated factor IX - accelerates the maximal velocity by 1000-fold (1)

  • factor VIII circulates in the plasma in a noncovalent complex with von Willebrand factor, vWF. VWF enhances factor VIII synthesis, protects it from proteolysis, and concentrates it at sites of active haemostasis (von Willebrand factor binds to subendothelial matrix proteins and adherent platelets).


  • Hoyer LW (1994). Hemophilia A. NEJM, 330(1), 38-46.

Related pages

Create an account to add page annotations

Annotations allow you to add information to this page that would be handy to have on hand during a consultation. E.g. a website or number. This information will always show when you visit this page.