genetic defect of haemoglobin due to a substitution of lysine for glutamic acid in the ß-globin chain at position 6 (same point as substitution in HbS)
frequent in West Africa
HbC tends to form rhomboidal crystals
in homozygotes - mild haemolytic anaemia with marked target cell formation, microspherocytes and cells with rhomboidal shape; splenomegaly
in heterozygotes (carriers) - a few target cells only
Annotations allow you to add information to this page that would be handy to have on hand during a consultation. E.g. a website or number. This information will always show when you visit this page.