This site is intended for healthcare professionals

Go to /sign-in page

You can view 5 more pages before signing in

DIC

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

Disseminated intravascular coagulation (DIC) is a conditon where the physiological generation of thrombin becomes unregulated.

A wide variety of triggers may cause release of thrombin into the circulation with consequent formation of microthrombi. It is these thrombi that cause tissue ischaemia and necrosis.

In an attempt to maintain vascular patency the fibrinolytic system becomes activated. Unregulated fibrinolysis and systemic fibrinogenolysis occurs with release of plasmin into the circulation.

The unregulated generation of thrombin and plasmin results in the thrombotic and haemorrhagic features of DIC.


Create an account to add page annotations

Annotations allow you to add information to this page that would be handy to have on hand during a consultation. E.g. a website or number. This information will always show when you visit this page.

The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.

Connect

Copyright 2024 Oxbridge Solutions Limited, a subsidiary of OmniaMed Communications Limited. All rights reserved. Any distribution or duplication of the information contained herein is strictly prohibited. Oxbridge Solutions receives funding from advertising but maintains editorial independence.