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Reduced production

Authoring team

Reduced proliferation of red cell precursors:

  • iron deficiency
  • anaemia of chronic disease
  • renal failure - reduced erythropoietin production
  • bone marrow disease:
    • aplastic anaemia
    • infiltrative disorders - leukaemia, myelofibrosis, cancer
  • pure red cell aplasia

Defective maturation of red cell precursors - increased erythropoietin, marrow hyperplasia but ineffective erythropoiesis due to:

  • defective nuclear maturation - megaloblastic anaemia
  • defective cytoplasmic maturation:
    • iron deficiency
    • disorders of globin synthesis - thalassaemia
    • disorders of haem metabolism - sideroblastic anaemia

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