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Spironolactone in female pattern hair loss (FPHL)

Authoring team

  • spironolactone is an aldosterone antagonist used in the treatment of hypertension and has also been used in the treatment of FPHL
    • spironolactone also possesses antiandrogenic properties, acting as an androgen receptor antagonist and reducing the levels of cytochrome P450-dependent enzymes 17beta-hydroxylase and desmolase, which are both required for androgen synthesis
    • spironolactone has been shown to be safe and effective in the treatment of female pattern hair loss (FPHL) in adults

Reference:

  • 1. Sinclair R, Wewerinke M, Jolley D. Treatment of female pattern hair loss with oral antiandrogens. Br. J. Dermatol. 2005; 152: 466-73.

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