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Toxicity and drug interactions

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  • nausea, vomiting, malaise, faintness and skin rashes have been reported.
  • adverse effects associated with prostaglandin administration: nausea, vomiting and diarrhoea.
  • adverse effects associated with the combination of gemeprost and mifepristone include abdominal pain from uterine contraction and uterine haemorrhage. The abdominal pain usually responds to paracetamol. Less than 1% of women require a transfusion or an emergency evacuation of the uterus to control vaginal bleeding.
  • avoid aspirin and non-steroidal anti-inflammatory drugs because they inhibit prostaglandin synthetase and therefore have a theoretical risk of reduction of efficacy.

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