A skin rash occurs in 5-10% of patients treated with lamotrigine (typically within the first 6 weeks of treatment). Serious skin reactions occur in about 1 in 1000 patients, including Stevens Johnson syndrome and toxic epidermal necrolysis. The risk of serious skin reactions is much higher in children with a frequency of 1:300 to 1:100 (1).
Risk factors for the development of skin reactions include (2):
Reference:
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