Anabolic steroids and hepatic effects
Hepatic:
- various abnormal liver function tests (elevated alkaline phosphatase, aminotransferases, conjugated bilirubin, and plasma proteins) have been associated with the use of anabolic androgenic steroids (AAS)
- jaundice occasionally occurs as a result of hypersensitivity-type reaction and is usually seen after 2-5 months of therapy
- cholestasis has been reported especially with the use of 17alpha-alkylated agents
- in the majority of cases, the rise in transaminases is transient, with levels normalizing within a few weeks of discontinuation of AAS
- peliosis hepatis and hepatocellular adenomas have been seen with the use of 17alpha-alkylated AAS
Reference:
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