You can view 5 more pages before signing in

Paternal factors

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

The paternal factors causing miscarriage include:

chromosomal translocations in the father may result in abnormal gametes and so cause spontaneous abortions. About 1:10 of couples with a history of recurrent abortion will have one partner with a chromosomal abnormality.
immunological factors: in some women who recurrently abort it has been shown that there is not the usual formation of maternal blocking antibodies in response to the husband's component of the foetal tissue antigens. This antibody response is necessary for the normal continuation of pregnancy and absence of this response is associated with the loss of an otherwise normal foetus. Some success has been claimed for infusing mothers with paternal lymphocytes before attempting a further pregnancy.
increasing age: numerous studies have shown that advanced paternal age may increase the risk of spontaneous abortion (1).

Reference:

(1) Kleinhaus K. Paternal Age and Spontaneous Abortion. Obstetrics & Gynecology 2006;108(2): 369-377

Create an account to add page annotations

Create a free account

Annotations allow you to add information to this page that would be handy to have on hand during a consultation. E.g. a website or number. This information will always show when you visit this page.